Retinal vasculitis: a novel paradoxical effect of anti-TNF ?
نویسندگان
چکیده
منابع مشابه
Anti-TNF-Alpha Therapy and Systemic Vasculitis
TNF-α is a pleiotropic cytokine, which plays a major role in the pathogenesis of numerous autoimmune and/or inflammatory systemic diseases. Systemic vasculitis constitutes a group of rare diseases, characterized by inflammation of the arterial or venous vessel wall, causing stenosis and thrombosis. Treatment of the different type of vasculitis mainly relies on steroids and immunosuppressive dru...
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The therapeutic options for anti-neutrophil cytoplasm antibody (ANCA)-associated systemic vasculitis (AASV) remain limited and hampered by adverse effects. One potential novel therapeutic avenue involves inhibition of TNF-alpha, with encouraging uncontrolled data in humans with one agent (infliximab) but disappointing controlled data from another (etanercept). For investigating the potential ro...
متن کاملRetinal vasculitis.
Evidence is now accumulating on both clinical and experimental grounds that the retina is an a priori source of inflammatory activity. Reactive inflammation in the retina may produce many of the clinical signs previously ascribed to uveal inflammation. Autoimmune mechanisms are probably responsible for the majority of cases of retinal vasculitis. Autoimmune retinal vasculitis occurs without oth...
متن کاملRetinal Vasculitis
Past Ocular History Approximately three years prior to presentation, the patient developed a gradual loss of vision in her left eye and noticed that 1pieces were missing from objects when viewed with the left eye. A diagnosis of 1pre-retinal fibrosis was made and symptoms persisted unchanged until about three months prior to presentation, when periorbital discomfort, a further decrease in visio...
متن کاملRetinal vasculitis.
Retinal vasculitis is a sight-threatening intraocular inflammation affecting the retinal vessels. It may occur as an isolated ocular condition, as a manifestation of infectious or neoplastic disorders, or in association with a systemic inflammatory disease. The search for an underlying etiology should be approached in a multidisciplinary fashion based on a thorough history, review of systems, p...
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ژورنال
عنوان ژورنال: Case Reports
سال: 2014
ISSN: 1757-790X
DOI: 10.1136/bcr-2014-204909